Serum myostatin and irisin as predictive biomarkers of sarcopenia, malnutrition and mortality in patients with decompensated liver cirrhosis

Malnutrition and sarcopenia are nowadays considered the main complications of liver cirrhosis (LC). Myokines signal peptides synthesized in muscles that regulate muscle strength mass mediate crosstalk between skeletal other organs. It is unknown whether circulating myokines can be used as biomarkers malnutrition have independent prognostic value LC. The purpose study was to assess relationship serum levels myostatin irisin with nutritional status, survival decompensated LC patients. 74 patients (55.30±11.40 years) were involved prospective study. Nutritional status assessed using Patient-Generated Subjective Global Assessment, Skeletal Muscle Index. concentration determined by enzyme immunoassay. Statistical data processing performed SPSS22 (© SPSS Inc.). established not related severity according Child-Turcotte-Pugh, Model For End-Stage Liver Disease, grade ascites. Patients overt encephalopathy higher levels. severe hypoalbuminemia lower development associated increased decreased concentration. Serum level predict (AUC 0.834 males 0.827 females, p<0.01). 0.830, p<0.001). mortality high (above 5.25 ng/ml 3.55 females) low (less than 1.72 ng/ml) significantly higher. In conclusion, may useful assessment prediction